Archive · 17 Dec 2025
Fixing Body Clock Rhythms in Mice Shrinks Tumors
Scientists found that in mice with breast cancer, the tumors mess up the natural daily rhythm of a stress hormone called corticosterone.
When they fixed this rhythm by stimulating certain brain cells at the right time of day, the tumors shrank.
This is because the fixed rhythm helped the immune system fight the cancer better.
The researchers think this could one day help make cancer treatments work better and have fewer side effects.
They're still trying to figure out exactly how this works and why the timing is so important.
Restoring corticosterone rhythms in mice with breast cancer reduced tumor size.
Tumors disrupt the natural day-night rhythm of corticosterone, a stress hormone.
Stimulating specific brain neurons at the right time of day restored the hormone rhythm.
This restoration increased the immune system's ability to fight the cancer.
The timing of the stimulation is crucial for the anti-cancer effect.
- Who
- Researchers led by Jeremy Borniger at Cold Spring Harbor Laboratory
- What
- Study on restoring corticosterone rhythms in mice with breast cancer
- When
- Not specified (ongoing research)
- Where
- Cold Spring Harbor Laboratory, USA
- Why
- To explore potential cancer treatments by targeting circadian rhythms
- Study Subject
- Mice with induced breast cancer
- Key Finding
- Restoring corticosterone rhythms reduced tumor size
- Research Team
- Led by Jeremy Borniger at Cold Spring Harbor Laboratory
- Method
- Chemogenetics to stimulate specific neurons
- Effective Timing
- Stimulation before light-to-dark transition
- Potential Benefit
- May boost effectiveness of cancer treatments