World's Rarest and Scariest Diseases: Overview

Sometimes, people get sick with diseases that are very uncommon.

This article talks about some of the rarest and most unusual diseases in the world.

One disease, RPI Deficiency, has only had one recorded case.

Others like Field’s disease cause muscles to get weaker.

Some diseases, like HGPS, make children age very quickly.

Some conditions cause unusual symptoms, such as having blue skin (Methemoglobinemia), getting hives from water (Aquagenic Urticaria), or suddenly speaking with a different accent (Foreign Accent Syndrome).

There are also severe genetic conditions like Lesch–Nyhan Syndrome, which can cause self-harm.

Kuru disease was spread through cannibalism.

Lastly, Harlequin Ichthyosis causes thick, plate-like scales.